Symbol
Name
ID

Nlgn3
neuroligin 3
MGI:2444609

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	EEG abnormality	Abnormal nonverbal communicative behavior	Delayed speech and language development	Lack of spontaneous play	Impaired ability to form peer relationships	Autism	Inflexible adherence to routines	Motor stereotypy	Restrictive behavior	Intellectual disability	Seizure
Disease(s) Associated with NLGN3
autistic disorder

Mouse Phenotypes

nervous system phenotype

decreased brain size

increased CNS synapse formation

impaired synaptic plasticity

decreased excitatory postsynaptic current amplitude

increased excitatory postsynaptic current amplitude

abnormal excitatory postsynaptic potential

abnormal glutamate-mediated receptor currents

reduced AMPA-mediated synaptic currents

abnormal inhibitory postsynaptic currents

abnormal miniature excitatory postsynaptic currents

decreased miniature inhibitory postsynaptic current frequency

absent long-term depression

Availability

Mouse Genotype

Nlgn3^tm1Bros/Nlgn3^tm1Bros

Nlgn3^tm3.1Sud/Nlgn3^tm3.1Sud

Nlgn3^tm1.1Htz/Y

Nlgn3^tm1Rhn/Y

Nlgn3^tm1Rhn/Y
Tg(Pcp2-tTA)3Horr/0

Nlgn3^tm1Sud/Y

Nlgn3^tm1Sud/Y
Tg(Drd1-tdTomato)5Calak/0

Nlgn3^tm2.1Sud/Y
Tg(Drd1-tdTomato)5Calak/0

Nlgn3^tm4.1Sud/Y
Tg(Pcp2-cre)2Mpin/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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